Prevalence of gastrointestinal pathogens in sub-saharan africa: Systematic review and meta-analysis

© S.M. Fletcher et al., 2011. A significant proportion of vulnerable people in sub-Saharan Africa (SSA) remain at risk for contracting diarrhoeal diseases due to the presence of many risk factors facilitating their transmission. A systematic review of published articles from the SSA region was done to determine the prevalence and types of diarrhoeal pathogens in circulation, based on a search of databases, including EBSCO host, PubMed, Scopus, Science Direct, Google scholar and Web of Science was done between September 2009 and December 2010. Data were summarized from 27 studies, with pooled data analysed and reported. Pathogens were isolated from between 26.8-65.6% of cases, with an overall isolation rate of 55.7% (95% CI, 48.2-62.9%). Isolation rates were highest amongst adult cases followed by children, and the odds of isolating a pathogen was greater in diarrhoeal cases (Odds Ratio 4.93 (95% CI, 1.99 to 12.23), than in asymptomatic controls. Overall isolation ranged from 8% to 99%; and heterogeneity testing suggests differences between age groups (Q=5.806; df=2, P=0. 055). Mixed E. coli spp., (29.95%), Cryptosporidium (21.52%), Cyclospora (18%), Entamoeba. (13.8%), Shigella spp. (10.49%), Salmonella spp. (8.36%), and Campylobacter spp. (8.33%), were most commonly reported, and rotavirus was the most common virus isolated. This is the first review to look at the range of enteric pathogens circulating in SSA, and has confirmed high rates of isolation of pathogens from diarrhoeal cases. Public health practitioners can use this information to understanding the challenges related to diarrhoeal illness and set priorities for their prevention and control

Does loyalty pay? First-time versus repeat visitors at a national arts festival

The aim of this research is to segment visitors to one of South Africa’s biggest arts festivals based on the frequency of visits in order to distinguish between fi rst-time and repeat festival attendees. Both first-time and repeat visitor groups play a fundamental role in the overall well-being and success of a festival, and festival organisers must strive to achieve a balance between first-time and repeat visitors. Festival managers should therefore be aware of the festival attributes that differentiate between the first-time visitor group and repeat visitors attending the festival. These differences include socio-demographics, behavioural characteristics, destination perception, perceived value and travel motivations. This article therefore compares first-time and repeat visitors to the Klein Karoo National Arts Festival based on these categories. A questionnaire survey (N = 555) was conducted at the festival, and the findings indicate that there are significant differences between first-time and repeat visitors at the festival. First-time visitors spend a significant amount of money during the festival and are mainly motivated by Relaxation and socialisation and Festival shows/productions ,while repeat visitors are loyal visitors who stay longer and spend more money, especially on tickets supporting the festival’s shows/productions. Results reveal that both first-time and repeat visitor groups are important for the long-term sustainability of the festival. This method of segmentation has proved to be successful and is used as the basis for proposing managerial and marketing implications for the festival organisers

Inhibition of food intake in obese subjects by peptide YY3-36

Background: The gut hormone fragment peptide YY3-36 (PYY) reduces appetite and food intake when infused into subjects of normal weight. In common with the adipocyte hormone leptin, PYY reduces food intake by modulating appetite circuits in the hypothalamus. However, in obesity there is a marked resistance to the action of leptin, which greatly limits its therapeutic effectiveness. We investigated whether obese subjects were also resistant to the anorectic effects of PYY.Methods: We compared the effects of PYY infusion on appetite and food intake in 12 obese and 12 lean subjects in a double-blind, placebo-controlled, crossover study. The plasma levels of PYY, ghrelin, leptin, and insulin were also determined.Results: Caloric intake during a buffet lunch offered two hours after the infusion of PYY was decreased by 30 percent in the obese subjects (P<0.001) and 31 percent in the lean subjects (P<0.001). PYY infusion also caused a significant decrease in the cumulative 24-hour caloric intake in both obese and lean subjects. PYY infusion reduced plasma levels of the appetite-stimulatory hormone ghrelin. Endogenous fasting and postprandial levels of PYY were significantly lower in obese subjects (the mean [+/-SE] fasting PYY levels were 10.2+/-0.7 pmol per liter in the obese group and 16.9+/-0.8 pmol per liter in the lean group, P<0.001). Furthermore, the fasting PYY levels correlated negatively with the body-mass index (r=-0.84, P<0.001).Conclusions: We found that obese subjects were not resistant to the anorectic effects of PYY. Endogenous PYY levels were low in the obese subjects, suggesting that PYY deficiency may contribute to the pathogenesis of obesity

Applicability of the Organisational Climate Description Questionnaire – Rutgers Elementary: A South African case study

The Organisational Climate Description Questionnaire – Rutgers  Elementary (OCDQ – RE) was used to determine the current organizational climate of primary schools in North-West Province, South Africa. This questionnaire evaluates the actions of principals and educators; the current organizational climate in primary schools can be determined from the results. A quantitative research approach, with 904 teachers from 68 schools, was used to determine the applicability of the measuring instrument. Exploratory and confirmatory factor analyses revealed that certain items measuring directive behaviour in the OCDQ-RE grouped with supportive behaviour of the principal. Hence, in this study, these items were regarded as supportive towards the educators and their work by the respondents. According to Cronbach’s alpha coefficient the questionnaire can be regarded as reliable. Recommendations are made to renderthe questionnaire even more applicable for the South African context.Keywords: improving organizational climate; organizational climate; OCDQ; primary schools; school climat

Evolution of the Stellar Mass-Metallicity Relation. II. Constraints on Galactic Outflows from the Mg Abundances of Quiescent Galaxies

We present the stellar mass–[Fe/H] and mass–[Mg/H] relation of quiescent galaxies in two galaxy clusters at z ~ 0.39 and z ~ 0.54. We derive the age, [Fe/H], and [Mg/Fe] for each individual galaxy using a full-spectrum fitting technique. By comparing with the relations for z ~ 0 Sloan Digital Sky Survey galaxies, we confirm our previous finding that the mass–[Fe/H] relation evolves with redshift. The mass–[Fe/H] relation at higher redshift has lower normalization and possibly steeper slope. However, based on our sample, the mass–[Mg/H] relation does not evolve over the observed redshift range. We use a simple analytic chemical evolution model to constrain the average outflow that these galaxies experience over their lifetime, via the calculation of mass-loading factor. We find that the average mass-loading factor η is a power-law function of galaxy stellar mass, $\eta \propto {M}_{* }^{-0.21\pm 0.09}$. The measured mass-loading factors are consistent with the results of other observational methods for outflow measurements and with the predictions where outflow is caused by star formation feedback in turbulent disks

Educators and the quality of their work environment: an analysis of the organisational climate in primary schools

The prevalent organisational climate in primary schools in the North West Province was determined in order to formulate management strategies to increase the organisational climate. For this purpose, a quantitative research method, founded in post-positivistic points of departure, was applied. In the process, the Organizational Climate Description Questionnaire &ndash; Rutgers Elementary (OCDQ-RE) was applied in order to determine the behaviour of principals and school educators. The investigation indicated that the behaviour of the principals and that of the educators contributed only to an average degree to the establishment of a more effective organisational climate in the primary schools investigated. Furthermore the exploratory and confirmatory factor analyses indicated that certain items in the original climate questionnaire, which were grouped in the directive behaviour of the principal, were viewed by the respondents in South Africa as supportive but, in some instances, also as restrictive.Keywords: educational environment; effective schools; improving organisational climate; improving school climate; management styles; Organizational Climate Description Questionnaire (OCDQ); organisational climate; primary schools; school climate; teacher morale and attitude

Epidemiology and associated risk factors of giardiasis in a peri-urban setting in New South Wales Australia

© 2018 Cambridge University Press. Giardiasis is one of the most important non-viral causes of human diarrhoea. Yet, little is known about the epidemiology of giardiasis in the context of developed countries such as Australia and there is a limited information about local sources of exposure to inform prevention strategies in New South Wales. This study aimed to (1) describe the epidemiology of giardiasis and (2) identify potential modifiable risk factors associated with giardiasis that are unique to south-western Sydney, Australia. A 1:2 matched case-control study of 190 confirmed giardiasis cases notified to the South-Western Local Health District Public Health Unit from January to December 2016 was employed to investigate the risk factors for giardiasis. Two groups of controls were selected to increase response rate; Pertussis cases and neighbourhood (NBH) controls. A matched analysis was carried out for both control groups separately. Variables with a significant odds ratio (OR) in the univariate analysis were placed into a multivariable regression for each matched group, respectively. In the regression model with the NBH controls, age and sex were controlled as potential confounders. Identified risk factors included being under 5 years of age (aOR = 7.08; 95% confidence intervals (CI) 1.02-49.36), having a household member diagnosed with a gastrointestinal illness (aOR = 15.89; 95% CI 1.53-164.60) and having contact with farm animals, domestic animals or wildlife (aOR = 3.03; 95% CI 1.08-8.54). Cases that travelled overseas were at increased risk of infection (aOR = 19.89; 95% CI 2.00-197.37) when compared with Pertussis cases. This study provides an update on the epidemiology and associated risk factors of a neglected tropical disease, which can inform enhanced surveillance and prevention strategies in the developed metropolitan areas

Ultrafast Diffusion at the Onset of Growth: O/Ru(0001).

Nanoscopic clustering in a 2D disordered phase is observed for oxygen on Ru(0001) at low coverages and high temperatures. We study the coexistence of quasistatic clusters (with a characteristic length of ∼9  Å) and highly mobile atomic oxygen which diffuses between the energy-inequivalent, threefold hollow sites of the substrate. We determine a surprisingly low activation energy for diffusion of 385±20  meV. The minimum of the O-O interadsorbate potential appears to be at lower separations than previously reported.Isaac Newton Trust, grant 17.37(j) Herchel Smith Fun